@article{MAKHILLJAVA20098111860,
    title = {Polymorphism in 5' Regulatory Region of the Porcine Fat Mass and Obesity Associated (FTO) Gene is Associated with Intramuscular Fat Content in a Jinhua x Pietrain F<sub>2</sub> Reference Population},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {8},
    number = {11},
    pages = {2329-2334},
    year = {2009},
    issn = {1680-5593},
    doi = {javaa.2009.2329.2334},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2009.2329.2334},
    author = {Zhang,Miao,Hua,Jiang,Lu and},
    keywords = {Porcine,regulatory polymorphism,fat mass and obesity associated gene,fat deposition},
    abstract = {As a newly described candidate gene in obesity, FTO gene showed a strong and highly significant association with the obesity-related traits in various human populations. It has been suggested that FTO gene play a key role in the regulation of energy balance and feed intake. Here we sequenced the -2.0 kb of the 5' flanking region of the porcine FTO gene, 7 SNPs were detected in this region and genotyped on the Jinhua x Pietrain F<sub>2</sub> reference population. Using a gene-wide haplotype-tagging approach, three tag SNPs were examined. The SNPs of g -1191 A&gt;G had significant associations with Intramuscular Fat (IMF) content (p&lt;0.05), but not with the Average Backfat Thickness (ABF), Leaf Fat weight (LF) or Average Daily Gain (ADG). Additionally, allele frequencies of the g -1191A&gt;G mutation were studied in 6 pig breeds and the G allele was mainly occurred in Chinese native pig breeds. These results provided the solid evidence that FTO gene was associated with the intramuscular fat deposition in pigs.}
    }