@article{MAKHILLJAVA20098101814,
    title = {Pharmacokinetics and Penetration into the Aqueous Humor of Long Action Oxytetracycline after Single Dose Intravenous and Intramuscular Administrations in Rabbits},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {8},
    number = {10},
    pages = {1900-1905},
    year = {2009},
    issn = {1680-5593},
    doi = {javaa.2009.1900.1905},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2009.1900.1905},
    author = {Feride,Ozgur,Zafer,Elif and},
    keywords = {Oxytetracycline,rabbit,aqueous humor,pharmacokinetics,plasma,intravenous},
    abstract = {The aim of this study was to investigate pharmacokinetics and penetration into the aqueous humor of Long Action Oxytetracycline (OTC-LA) after Intravenous (IV) and Intramuscular (IM) administrations, at a single dose of 20 mg kg<SUP>-1</SUP> b.wt in rabbits. After administrations of the long action formulation, the plasma oxytetracycline concentrations were evaluated using a two-compartmental open model. The study was designed according to a two-period cross-over and the plasma OTC concentration was measured using the ELISA procedure. The elimination half-lives (t<SUB>1/2β</SUB>) of the OTC-LA after IV and IM administrations were 12.60±0.92 and 38.67±4.40 h, respectively. After IV administration, the volume of distribution (V<SUB>dss</SUB>) and total body Clearance (Cl<SUB>tot</SUB>) values of the drug were 3.42±0.21 L kg<SUP>-1</SUP> and 0.19±0.01 L/h/kg, respectively. The maximum concentration of the drug (C<SUB>max</SUB>) in the plasma (4.23±0.43 μg mL<SUP>-1</SUP>) was achieved at 2.0 h (t<SUB>max</SUB>) after IM administration. The Minimum therapeutic plasma Concentration (MIC) of the drug at the amount ≥0.5 μg mL<SUP>-1</SUP> was maintained until 48 h after IV and IM administrations. The intramuscular bioavailability of the drug was 0.79±0.10%. After IV and IM administrations of OTC-LA formulation, the maximum concentrations of the drug in the aqueous humor were 0.1 and 0.068 μg mL<SUP>-1</SUP>, respectively. However, the concentrations of the drug in the aqueous humor were below the MIC value (0.5 μg mL<SUP>-1</SUP>) during 12-72 and 4-48 h for IM and IV administrations, respectively.}
    }