@article{MAKHILLJAVA2008781186,
    title = {The Humoral Immun Response of Mice to Liposomes Containing <I>Brucella melitensis </I>Outer Membrane Fragments},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {7},
    number = {8},
    pages = {991-995},
    year = {2008},
    issn = {1680-5593},
    doi = {javaa.2008.991.995},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2008.991.995},
    author = {Fatma Kaynak Onurdag,Tuncer Degim,Zelihagul De im,Ismail Kutlu,Ozgur Kaynar,Gulsen Gunes and},
    keywords = {Electrolyte balance,eggshell,performance,laying hens},
    abstract = {Brucellosis is an important zoonotic disease and the prevention is made by vaccination of animals. For ewes <I>Brucella melitensis</I> REV-1 live attenuated vaccine is widely used but because of some risks such as being infected during the vaccination, re-infection of animals, a new vaccine with less side effect is need to be improved. In this study it was aimed to determine a strong humoral immune response by encapsulating the <I>Brucella</I> outer membrane antigens with the optimum liposome formulation and the statistical analyses showed that the <I>Brucella</I> outer membrane extract encapsulated with liposome can evoke humoral immune response better than live attenuated <I>B. melitensis </I>REV-1 vaccine in mice.}
    }