@article{MAKHILLJAVA200876903,
    title = {<I>In situ</I> Analysis of CD4, CD8 and Mast Cells in Lung of <I>Mycoplasma hyopneumoniae</I> Experimentally Infected Pigs},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {7},
    number = {6},
    pages = {752-758},
    year = {2008},
    issn = {1680-5593},
    doi = {javaa.2008.752.758},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2008.752.758},
    author = {Tonatiuh Alejandro Cruz Sanchez,Socorro Sandra Martinez Robles,German Garrido Farina,Jorge Tortora Perez,Susana Mendoza Elvira,Abel Ciprian Carrasco,Eliseo Hernandez Baumgharten,Andres Romero Rojas and},
    keywords = {Mycoplasma hyopneumoniae,Immune response,CD4,CD8,Mast cell,swine lung},
    abstract = {Mast cells (MC) and CD4<SUP>+</SUP> and CD8<SUP>+</SUP> cell subpopulations, from the apical border of the right cranial lobe of lungs of pigs experimentally infected with <I>Mycoplasma hyopneumoniae</I>, were histologically (MC) and immunohistochemically (CD4 and CD8) analyzed during the first 20 days post infection (PI). Twelve weaned,  four-week-old  healthy  pigs  were endotracheally inoculated with a lung homogenate infected with <I>M. hyopneumoniae</I>, strain 194 and 6 control animals were inoculated with Friis medium only. A control animal and two infected animals were euthanized at days 0, 4, 8, 12, 16 and 20 PI. <I>M. hyopneumoniae</I> induced an early increase of CD4 cells at day 4 PI (p&lt;0.001) and at day 8 PI there was a significant and coincident increase in all three cell populations (p&lt;0.001), which intermittently persisted until day 20 (CD8 p&lt;0.001, MC p&lt;0.001). The results of this work suggest that infection with <I>M. hyopneumoniae</I> induces an early response of CD4+ cells, followed by an infiltration of CD8+ cells and MCs, possibly related to the pathophysiological events of the disease, since, despite the evident immune infiltration, the infection continued its course.}
    }