@article{MAKHILLJAVA200874590,
    title = {Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {7},
    number = {4},
    pages = {433-436},
    year = {2008},
    issn = {1680-5593},
    doi = {javaa.2008.433.436},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2008.433.436},
    author = {Samia A.A. Hassan,Sana A.I. Shaddad,A.K. Muddathir,I.B. El-Tayeb,A.O.M. Nour,M.H. Al-Nazawi and},
    keywords = {Pharmacokinetic,intramuscular,long-acting oxytetracycline,sheep},
    abstract = {The pharmacokinetics of long-acting Oxytetracycline (OTC) formulation (Alamycin-LA) was studied after intramuscular (IM) route at a dose of 1 mg kg <SUP>1</SUP> body weight to fifteen healthy desert sheep. The mean C<SUB>max</SUB> values of 74.8±13.22 µg mL <SUP>1</SUP> was after 0.9±0.13 h, the mean distribution phase was 2.0±0.4 h and the apparent elimination half-life was 126±23 h. The volume of distribution (V<SUB>d</SUB>) was found to be 67.933±4.88 L. The area under the curve (AUC<SUP>0</SUP><SUB>240</SUB>) and the area under concentration-time curve (AUMC) were 2530.26±203.3, 242522.2±48504.5 µg/ml/h<SUP>2</SUP>, respectively. The total body clearance (cl<SUB> </SUB>) was 373.63±18.9 mL h <SUP>1</SUP> while the mean resident time (MRT) was 90.61±13.8 h.}
    }