@article{MAKHILLJAVA20087111541,
    title = {Effects of Dietary Taurine and Gamma Aminobutyric Acid on the Steroil CoA Desaturase and  6, 5 Desaturase Enzyme Activities in Liver Tissues of Rats},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {7},
    number = {11},
    pages = {1450-1457},
    year = {2008},
    issn = {1680-5593},
    doi = {javaa.2008.1450.1457},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2008.1450.1457},
    author = {Yusuf Ozkan,Okkes Yilmaz,Mehmet Tuzcu,Gulsen Murat,Mehmet Guvenc,Ali Ihsan ozturk and},
    keywords = {Taurine,gamma amino butyric acid,lipid,GSH,cholesterol,fatty acids},
    abstract = {In this study, the effects of dietary taurine (2-amino ethane sulphonic acid) (TAUR) and Gamma Amino Butyric Acid (GABA) on the levels of reduced glutathione (GSH), lipid and fatty acid composition in liver tissues of 3 and 8 months female wistar rats was evaluated. The<I> </I>rats (n = 48) were randomly assigned to 8 treatment groups consisting of 6 rats each. The rats (both 3 and 8 month old) were fed a basal diet (Control) or basal diet plus taurine given by drinking water (500 mg kg<SUP>-1</SUP>) (TAUR groups) or basal diet plus GABA given by drinking water (500 mg kg<SUP>-1</SUP>) (GABA) or basal diet plus the combinations of GABA and TAUR given by drinking water (500 + 500 mg kg<SUP>-1</SUP>) (GABA+TAUR groups). In 3 month old rats, the lipid level in GABA and GABA+TAUR groups was higher than control group (p&lt;0.01). GSH level was high in the TAUR group (p&lt;0.05). While, the lipid level increased in GABA group of 8 month old rats, its level decreased in TAUR group (p&lt;0.05). The level of GSH in GABA, TAUR and GABA+TAUR groups was lower than control group (p&lt;0.01). Oleic acid level (18:1, n-9) was high in TAUR group (p&lt;0.05) and linoleic acid level (18:2, n-6) GABA and GABA+TAUR groups was higher than control group (p&lt;0.01) in 3 month old rats. However, arachidonic acid level (20:4, n-6) in supplemented groups was lower than control group (p&lt;0.01). While, the saturated fatty acid level increased in the supplemented groups, unsaturated fatty acid decreased in the same groups (p&lt;0.05). In 8 month old rats, palmitic acid level (16:0) increased in supplemented groups (p 0.05), but stearic acid level decreased in the same groups. The levels of oleic and linoleic acids were high in GABA and GABA+TAUR groups. Arachidonic and docosahexaenoic acid levels in GABA and GABA+TAUR groups were lower than control group (p&lt;0.01). The level of saturated fatty acid level was high in the GABA and TAUR groups, but the unsaturated fatty acid was low in the same groups (p&lt;0.05). In conclusion, present study showed that the products of  6 desaturation pathway such as arachidonic acid was decreased by the GABA and taurine in 3 and 8 months old of female rats. Conversely, the products of steroil CoA desaturase were increased by dietary taurine treatment.}
    }