@article{MAKHILLJAVA200765715,
    title = {Effects of <I>Nigella sativa</I> L. and <I>Urtica dioica</I> L. On the Numbers of Mast Cells in the Thymus, Spleen and Mesenteric Lymph Nodes of Rats with Carbon Tetrachloride Toxicity},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {6},
    number = {5},
    pages = {601-605},
    year = {2007},
    issn = {1680-5593},
    doi = {javaa.2007.601.605},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2007.601.605},
    author = {Mecit Yoruk,Turan Karaca and},
    keywords = {Nigella sativa,Urtica dioica,thymus,spleen,mesenteric lymph node,mast cell,carbon tetrachloride},
    abstract = {This study investigated the effects of <I>Nigella Sativa</I> L. (NS) and <I>Urtica Dioica</I> L. (UD) on the number of Mast Cells (MCs) in Carbon tetrachloride (CCl<SUB>4</SUB>)-treated rats. A total of 35 healthy male Sprague-Dawley rats were divided into 5 equal groups. All groups, expect control group, were injected subcutaneously  with  0.8  mL CCl<SUB>4 </SUB>per kg body weight twice a week for 45 days and then CCl<SUB>4</SUB> + UD-treated, CCl<SUB>4</SUB> + NS-treated and CCl<SUB>4</SUB> + UD + NS-treated rats received a daily intraperitoneal injection of 0.2 mL kg <SUP>1</SUP> NS or/and 2 mL kg <SUP>1</SUP> UD oils for 45 days starting on day 46. Thymus, spleen and mesenteric lymph nodes were sampled, stained with 1% aqueous toluidine blue and examined microscopically. The thymus, spleen and lymph nodes of CCl<SUB>4</SUB>-exposed animals contained significantly increased numbers of MCs compared with control group, CCl<SUB>4</SUB> + UD-treated, CCl<SUB>4</SUB> + NS-treated and CCl<SUB>4</SUB> + UD + NS-treated rats (p< 0.05). However, when exposed rats were also treated with UD, NS or UD + NS, a decrease in MCs was observed. These results demonstrate that UD and NS decrease the number of MCs induced by CCl<SUB>4</SUB> in the lymphoid tissues of rats.}
    }