@article{MAKHILLJAVA200762265,
    title = {Pathological Changes in Mice Experimentally Injected <I>Clostridium chauvoei</I> Toxins},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {6},
    number = {2},
    pages = {234-237},
    year = {2007},
    issn = {1680-5593},
    doi = {javaa.2007.234.237},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2007.234.237},
    author = {M.Y. Sugun,H.M. Kazeem,N.D.G. Ibrahim,N.M. Useh,L.B. Tekdek and},
    keywords = {Pathological changes,mice,Clostridium chauvoei,toxins},
    abstract = {Blackleg is an economically important disease of cattle, sheep and other ruminants which is endemic in both developed and developing countries of the world. Toxins and neuraminidase produced by <I>Clostridium chauvoei</I> have been reported to play significant complimentary roles in the pathogenesis of the disease. In this study, the pathological changes caused by exogenous toxins produced following the culture of <I>C. chauvoei </I>at 24 and 48 h respectively were investigated and it was observed that the 24 h toxin produced more severe pathological changes, compared to the 48 h toxin. Necrosis was observed in the tissues examined, both grossly and histopathologically and was attributed probably to impaired cellular (mitochondrial) respiration. It was concluded that, although toxins produced by <I>C. chauvoei </I>play an important role in the mechanisms of blackleg, the role of leukotrienes (C4, D4 and E4), cytokines (interleukin-1, IL-1; tumour necrosis factor- , TNF- ), platelet-activating factor, interferon, complement fragments (anaphylatoxins C5a and C3a), prostaglandins and neuraminidase in the pathogenesis of <I>C. chauvoei</I> infection in mice need to be thoroughly investigated.}
    }