@article{MAKHILLJAVA200762258,
    title = {Comparison of the Royal Jelly and Povidone Iodine on Wound Healing in Rabbits},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {6},
    number = {2},
    pages = {203-205},
    year = {2007},
    issn = {1680-5593},
    doi = {javaa.2007.203.205},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2007.203.205},
    author = {Fusun Karacal Temamo ullari,Ali Hayat and},
    keywords = {Royal jelly,skin wound,rabbit,specimens,inflammatory,histopathological},
    abstract = {The  effects  of  Royal  Jelly (RJ) on wound healing were investigated and compared to commonly used  10%  povidone  iodine  and   0.9%   sodium   chloride   treatment.   Three   full-thickness   skin  defects, 3,14 cm in diameter, were created on dorsal aspects of 12 rabbits. Wound surfaces were macroscopically examinated from the points of exudation, beginning of the contraction, granulation tissue and epithelization during  the  postoperative period. Biopsy specimens which were collected on the 4th, 8th, 12th and 16th Postoperative  Days  (POD)  were  evaluated  for histopathological changes. Specimens were evaluated according  to  several  histopathologic  parameters,  such  as  the thickness of scar tissue, the density of vascular proliferation and the degree of inflammatory cell infiltration. SPSS 11.0 for windows was used for statistical analyses. Thickness of scar tissue was significantly changed between the treatments of RJ and 0.9% sodium  chloride  (p<0.05),  while  the  wound  treatment  with  10%  povidone  iodine  and  0.9 % sodium chloride created similar results (p>0.05). The density of vascular proliferation between study groups was significantly different only on POD 4 and 16 (p<0.05). The degree of inflammatory cell infiltration was similar in all groups (p> 0.05), but a significant difference between the 10% povidone iodine and 0.9 % sodium chloride treatments on PODs 12 as an exception (p<0.05). In conclusion, daily topical royal jelly application to full-thickness skin defects in rabbit accelerated wound healing. Other adventages of RJ are ease of application and the low cost.}
    }