@article{MAKHILLJAVA200653383,
    title = {Chiral Inversion of R-(-)-Fenoprofen Enantiomer in Cats with Toxic Hepatic Disease},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {5},
    number = {3},
    pages = {176-183},
    year = {2006},
    issn = {1680-5593},
    doi = {javaa.2006.176.183},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2006.176.183},
    author = {Castro, E.,A. Soraci,O. Tapia,F. Fogel,R. Franci,L. Denzoin and},
    keywords = {Fenoprofen,cats,enantioselective,chiral inversion,carbon tethrachloride},
    abstract = {The 2-arylpropionic acids (2-APA) or profens, is a family of Non-Steroidal Anti-Inflamatory Drug (NSAIDS), widely used in human and veterinary medicine for the treatment of the arthritis, musculoskeletal disorders and hyperthermia. The molecule of fenoprofen (FPF), a member of the familiy of 2-APA, contains an asymetric carbon atom and exists as two enantiomeric forms, R-(-) fenoprofen and S-(+) fenoprofen . The R-(-) FPF enantiomer is metabolically inverted to their optic antipode, the S-(+) FPF enantiomer as result of the action of a metabolic pathway known as chiral inversion. The liver is the principal site for the 2-APA biotransformation. Severe hepatic disease should alter the percentage of chiral inversion obtained for R-(-) FPF. To test this hypothesis we studied the chiral inversion of R-(-) FPF in cats with toxic hepatic disease (THD) induced by carbon tethrachloride (CCl<SUB>4</SUB>). The percentage of chiral inversion in animals with THD was 90.5±21.1 (mean±sd) and the difference with healthy animals was not statistically significant.}
    }