@article{MAKHILLJAVA20065121614,
    title = {Protective Effect of <I>Spirulina platensis</I> Against Lead Toxication in Rats},
    journal = {Journal of Animal and Veterinary Advances},
    volume = {5},
    number = {12},
    pages = {1113-1116},
    year = {2006},
    issn = {1680-5593},
    doi = {javaa.2006.1113.1116},
    url = {https://makhillpublications.co/view-article.php?issn=1680-5593&doi=javaa.2006.1113.1116},
    author = {Ali Karadeniz and},
    keywords = {Spirulina platensis,lead,oxidant,antioxidant,rat},
    abstract = {It is known that <I>spirulina</I> is rich from the point of view of vitamin, mineral, essential fatty acids and antioxidants such as caretinoids. In this study, the changes on oxidant and antioxidant system occured by <I>spirulina</I> and protective effect of <I>spirulina</I> against lipid peroxidation in lead toxication in rats are examined. Forty adult female wistar albino rats were divided into four experimental groups: control, <I>spirulina</I>, lead and <I>spirulina</I> + lead-treated. At the end of the experimental period (1 month), animals in all four groups were fasted for 12 h and blood samples were taken for the determination malondialdehyde (MDA), reduced glutathione (GSH), ascorbic acid, nitrate and nitrite levels. There was a statistically significant difference between the groups for all parameters except for serum ascorbic acid. It is determined that there was a crucial increase in the level of GSH belonging to <I>spirulina</I> treated group when compared with control group, lead treated group and <I>spirulina</I> + lead treated group (p&lt;0,05). It was observed that the lecvel of MDA which is an important sign of lipid peroxidation for lead treated group is statistically crucial when compared with control group and <I>spirulina</I> treated group when compared with the other groups and this increase is statistically important (p&lt;0.05). Morover, it is seen that there is an increase in the level of nitrate and nitrite for <I>spirulina</I> treated group when compared with the other groups and this increase is statistically important (p&lt;0.05). Consequently, it is indicated that lipid peroxidation occured an animals treated by lead is prevented by the future of antioxidant of <I>spirulina platensis</I> and therefore it assists the level of antioxidants in circulation.}
    }