International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
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Abstract
Hepatitis C virus is an important cause of chronic hepatitis and primary hepatocellular carcinoma. HCV genotypes can vary in pathogenicity and can have an impact on treatment outcome. The analysis of Hepatitis C virus genotypes has become an important factor for planning treatment. Present study was aimed to study prevalence of HCV and its correlation with genotypes in chronic liver disease patients attending a tertiary care center, Coimbatore. Present study was single‐center, prospective, observational study, conducted in patients with chronic liver disease subjected to Anti‐HCV ELISA and RT‐PCR. Genotyping is done by RT‐PCR. Among 200 patients, majority belong to age group between 41‐70 years (76.5%). 110 (55%) were males and 90(45%) were females respectively. Out of 200 patients tested for Anti‐HCV antibodies by ELISA, 56 (28%) were positive. Out of 61 cases of chronic hepatitis, 14 (22.9%) and from 133 cases of cirrhosis 38 (28.6%) were positive for Anti‐HCV antibodies by ELISA. 29 (14.5%) were detected to have HCV RNA. 26 (13%) samples had been found to be positive by both ELISA and PCR. Genotype 3 was most common type observed in 17(58.6%) in this study followed by the genotype 4 which was seen in 6 (20.6%) cases. Four cases (13.7%) showed genotype 1 and genotype other than 1‐4 was also observed in 2 (6.9%) cases. The present study highlighted that HCV genotype 3 is the predominant genotype among chronic liver disease in our geographical area.
How to cite this article:
S. Viji, V. M. Theeba and M. Banumathy. Prevalence of Hepatitis C Virus and its Correlation with Genotypes in Chronic Liver Disease Patients Attending a Tertiary Care Center, Coimbatore.
DOI: https://doi.org/10.36478/10.59218/makijtm.2023.2.18.22
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2023.2.18.22