Hussein Ali Ahmed, Biochemical Study of New Cyclic Organic Compounds from Aldol Reaction, ACE Journal of Advance Research in Chemical Sciences, Volume 3,Issue 1, 2023, Pages 1-9, ISSN 2520-3703, acejarcs.2023.1.9, (https://makhillpublications.co/view-article.php?doi=acejarcs.2023.1.9) Abstract: The aldol reaction is one of the basic reactions in building the basic organic compounds for many medicines, medical drugs and treatments, which was and still is the cornerstone of cyclic chemistry through organic addition and formation reactions of three-component reactions and others.The aldol reaction was one of the long-established reactions in organic synthesis chemistry, especially in the preparation of ligands, coordination chemistry, organic reagents, analytical reagents, biochemistry, as well as ammonium chemistry because of its paramount importance and several applications. All new manufactured organic compounds recognized through forms of instrumental approaches like (FT.IR ,H.NMR, Mass)–spectr0photometric and 0ther chemical studies, as well as estimation 0f equipped c0mpounds as bio-c0mpounds Keywords: Aldole; chalcone; six membered; antimicrobial; heterocyclic; insertion reaction.