M.N. Islam, M.A.S. Haque, M.S. Alam, Study of Waveform Sampling Front-End ASIC Development for GSO/APD with DOI Information, International Journal of System Signal Control and Engineering Application, Volume 15,Issue 1, 2022, Pages 1-3, ISSN 1997-5422, ijssceapp.2022.1.3, (https://makhillpublications.co/view-article.php?doi=ijssceapp.2022.1.3) Abstract: Study of Waveform Sampling Front-End (WSFE) Application Specific Integrated Circuit (ASIC) development for GSO/APD with DOI Information has been presented in this research. This study confined to a detector module multi-array avalanche photodiodes (APD) with GSO crystal for high resolution animal PET, Depth-of-Interaction (DOI) information by pulse shape discrimination and multi-channel waveform sampling front-end ASIC. Study reveals that APD has shown better performance compared with PMTs for a given geometry and radiopharmaceuticals while individual readout of detector have better resolution and counting rate over light sharing or charge division schemes. Each channel of the WSFE ASIC which has been fabricated on a 4.9×4.9 mm wafer using Rohm 0.35 μ CMOS ASIC development technology comprises of a preamplifier, a Variable Gain Amplifier (VGA) and a fast Analog to Digital Converter (ADC) to digitize signals from the APD. Micrograph, design specifications, performance and test results of the WSFE chip for individual components have been presented as well. Keywords: Application Specific Integrated Circuit (ASIC);APD;WSFE;DOI;PET