Samia A.A. Hassan  , Sania A.I. Shaddad  , I.B. ElTayeb  , M.A. Omer  , M.H. Al-Nazawi  , A.M. Homeida  , 
    Detection of Tylosin Residue Levels Following Intramuscular Injection in Desert Sheep,
    Research Journal of Pharmacology,
    Volume 2,Issue 1,
    2008,
    Pages 1-3,
    ISSN 1815-9362,
    rjpharm.2008.1.3,
    (https://makhillpublications.co/view-article.php?doi=rjpharm.2008.1.3)
    Abstract: A total of 12 healthy desert sheep were injected intramuscularly with multiple doses of 5 g kg<SUP>-1</SUP> tylosin. Samples were collected at time 1, 3, 7 and 10 days after drug administrations. Tylosin was detected using microbiological method. Tylosin concentrations in different tissue were detected. High concentration of 61.78±5.83,  315.97±73.07  and  3956±645.59  µg g<SUP>-1</SUP> were  detected in liver, kidney and muscle, respectively at day 1. The highest concentrations of 19185±2966.9 µg g<SUP>-1</SUP> were noted at the site of injection at day 1 and persisted for 10 days. Low concentrations of 1.00, 1.5±0.24 and 5.22±0.20 µg g<SUP>-1</SUP> were noted in the liver, kidney and muscle at day 10, respectively. It is suggested that high tissue levels may create a reservoir of drug from which drug was released slowly into the circulation.
    Keywords: Residue;intramuscular;tylosin;sheep