Syamsudin  , S. Wahyuono  , S. Tjokrosonto  , Mustofa  , 
    <I>In vivo</I> Antiplasmodial Activity and Acute Toxicity of the Fraction of the <I>Garcinia parvifolia</I> Miq. Stem Bark,
    Research Journal of Pharmacology,
    Volume 1,Issue 4,
    2007,
    Pages 79-83,
    ISSN 1815-9362,
    rjpharm.2007.79.83,
    (https://makhillpublications.co/view-article.php?doi=rjpharm.2007.79.83)
    Abstract: The study of <I>in vivo</I> antiplasmodial activity and acute toxicity of the active fraction of <I>Garcinia parvifolia</I> Miq has been conducted. The fraction was obtained by maceration of n-hexane extract with methanol. A standard 4-day test on P. berghei infected Swiss mice was used to evaluate the <I>in vivo</I> antiplasmodial activity after an oral administration of  the  fraction  in  series dose of 25-200 mg kg <SUP>1</SUP> BW once daily for 4 consecutive days. The <I>in vivo</I> antiplasmodial  activity  was expressed by the dose inhibiting 50% of parasite growth (ED<SUB>50</SUB>). Acute toxicity was evaluated in Swiss mice after oral administration of the active fraction in series dose of 2000-8000 mg kg <SUP>1</SUP> BW. The acute toxicity was expressed by the dose leading 50% deaths (LD<SUB>50</SUB>). The results showed that the active fraction of <I>G. parvifolia</I> Miq was active against P. berghei in mice with an ED<SUB>50 </SUB>of 74.45 mg/kg BW/d. In addition, the active fraction was also relatively safe as expressed by the LD<SUB>50</SUB> of 8.000 mg kg <SUP>1</SUP> BW.
    Keywords: Antiplasmodial;acute toxicity;active fraction;Garcinia parvifolia Miq