Ali  Yousif Babiker, Mohammed S.  Abdelaziz, Hagir E.  Mohagir, Mohamed A.  Alsahli, Saleh A.  Almatroodi, Arshad H.  Rahmani, 
    Immunohistochemical Detection of Alpha-Methyl-Co-Racemase
(AMACR) in Adenocarcinoma of Prostate,
    Research Journal of Medical Sciences,
    Volume 10,Issue 6,
    2016,
    Pages 707-710,
    ISSN 1815-9346,
    rjmsci.2016.707.710,
    (https://makhillpublications.co/view-article.php?doi=rjmsci.2016.707.710)
    Abstract: The aim of study was to evaluate the expression pattern of Alpha-methylacyl-CoA Racemase
(AMACR) in prostate tumors. In order to examine the relationship between AMCAR expression and tumor, we
analyzed a total of 10 cases of benign prostatic hyperplasia and 20 cases of prostate adenocarcinoma .
Expressions pattern of AMCAR were analysed and found that only one case (10%) of benign prostatic
hyperplasia showed expression whereas 19 cases (95%) of prostate adenocarcinoma showed expression at
different levels of intensity. The difference in expression pattern among benign prostatic hyperplasia and
prostate adenocarcinoma was statically significant (p>0.05). Expression profile were further categorised
according to grade of the tumor and found that AMCAR was expressed in 4 (100%), 6 (100%) and 9 (90%) in
well, moderate and poor differentiated prostate adenocarcinoma respectively. This difference of expression
among the different types of grade was statistically insignificant (p>0.05). Our results concluded that AMCAR
is a valuable diagnostic and prognostic marker of prostate cancer and one of the vital factors in pathogenesis
of prostrate adenocarcinoma.
    Keywords: Prostate tumor;AMACR expression IHC;adenocarcinoma;vital factors;Saudi Arabia