S.F.  Ige, R.E.  Akhigbe, A.O.  Akinsanya, 
    The Role of Hyperglycemia in Skin Wrinkle Formation: Mediation of Advanced Glycation End-Products,
    Research Journal of Medical Sciences,
    Volume 4,Issue 5,
    2010,
    Pages 324-329,
    ISSN 1815-9346,
    rjmsci.2010.324.329,
    (https://makhillpublications.co/view-article.php?doi=rjmsci.2010.324.329)
    Abstract: Aging is a process of changes that occur within a system over a period of time. It is due to the variation in the continuous activities that maintain life. Changes that occur in aging can be seen in various parts of the body system but most especially in the skin. This study reviews the role and mechanism of Advanced Glycation End products (AGES) in skin wrinkle formation. Literature searches were conducted. Literatures concerning hyperglycemia and skin wrinkles were used focusing on the mechanisms of AGES. This study reveals that AGEs increases the stiffness and reduces the elasticity of the skin increases oxidative stress with resultant destruction of skin fibroblasts by increasing vascular permeability, inhibiting vascular dilatation and enhancing oxidative stress.
    Keywords: Hyperglycemia;skin wrinkles;agingoxidative stress;advanced glycation end products;Nigeria