C.  Senthil, N. Tharana Shamim, Valarmathi  , 
    Assessment of Cardiac Injury in Sepsis and Its Relation to in‐Hospital Mortality: A Clinical Study,
    Research Journal of Medical Sciences,
    Volume 19,Issue 4,
    2025,
    Pages 143-147,
    ISSN 1815-9346,
    makrjms.2025.4.143.147,
    (https://makhillpublications.co/view-article.php?doi=makrjms.2025.4.143.147)
    Abstract: Sepsis is a major cause of morbidity and mortality in hospitalized patients,
often involving multiple organ dysfunctions, including the heart.
Myocardial injury, identified by elevated troponin levels, is increasingly
recognized in sepsis, but its prognostic significance remains underutilized
in routine practice. This study evaluates the incidence of cardiac injury in
sepsis and its association with clinical outcomes, particularly in‐hospital
mortality. To assess the incidence of myocardial injury in sepsis patients
using serum troponin I levels and evaluate its association with
echocardiographic findings, blood culture results, ICU stay duration and
in‐hospital mortality. This was a hospital‐based observational study
conducted in the Department of Medicine, ACS Medical College and
Hospital, Chennai. A total of 50 adult patients with sepsis, diagnosed as
per Sepsis‐3 criteria, were enrolled. Serum troponin I levels were
measured within 24 hours of admission. Echocardiography was
performed within 48 hours. Data on demographics, laboratory tests, ECG,
blood culture, ICU stay and mortality were collected. Statistical analysis
was done using SPSS software. Myocardial injury (troponin I >0.04 ng/mL)
was observed in 44% of patients. In‐hospital mortality was significantly
higher among those with myocardial injury (45.5%) compared to those
without (17.8%). Left ventricular dysfunction (EF <45%) was noted in 36%
of patients with elevated troponin, versus 7% in the normal troponin
group. Mean ICU stay was longer in patients with myocardial injury
(7.8±2.4 days) compared to those without (4.6±1.8 days). Blood culture
positivity was also more frequent in the myocardial injury group (64% vs
50%). Myocardial injury is a frequent and clinically relevant complication
in sepsis, associated with increased mortality, prolonged ICU stay and
cardiac dysfunction. Early detection using troponin I and
echocardiography may aid in risk stratification and improve outcomes.
Routine cardiac evaluation should be considered in sepsis management
protocols.
    Keywords: Cardiac injury; sepsis; troponin; echocardiography; blood culture