Anita  Meena, Renu  Jain, Nisha  Yadav, Jagrati  Gupta, 
    To Assess the Role of Vaginal Micronised Progesterone as a Tocolytic Therapy in Arrested Preterm Labour,
    Research Journal of Medical Sciences,
    Volume 18,Issue 10,
    2024,
    Pages 599-603,
    ISSN 1815-9346,
    makrjms.2024.10.599.603,
    (https://makhillpublications.co/view-article.php?doi=makrjms.2024.10.599.603)
    Abstract: <p style="text-align:justify">Women with preterm labour that is arrested with tocolytic therapy are at increased risk of recurrent preterm labour. The efficacy of progesterone tocolytic therapy after successful arrest of preterm labour remains controversial Aim of this study to evaluate role of vaginal micronized progesterone in arrested preterm labour. Pregnant women who were arrested with acute tocolysis as evidenced by a 12 hour contraction free period were randomized into study and control groups. The study group received 400 mg of vaginal micronized progesterone daily, while the control group did not receive any drug. The patients were followed up till 37 completed weeks. Maternal and fetal outcomes were compared in both the groups In the present study majority of the women were 21‐25 years age in both the groups, the period of gestation at delivery was significantly (p&lt;0.05) high in progesterone group (37‐40 weeks) as compared to that in control group (34‐36.6 weeks). Lower segment cesarean sections (LSCS) was higher in progesterone group (57.1%) as compared to control group (34.3%). In Recurrence rate of preterm labour was significantly lower (75.7%) in progesterone group as compared to control group (82.8%). Vaginal micronized progesterone as a tocolytic therapy following an episode of arrested pre‐term labor significantly increased the duration to delivery interval., reduces the recurrence of preterm labour and also reduced the rate of Preterm birth.</p>

    Keywords: Micronized progesterone; preterm labor; delivery interval; gestational age; tocolysis