V. Jothi Lakshmi, R.  Shanker, 
    Treatment of Severe Anemia with Oral Supplements and Methylcobalamine Injection,
    Research Journal of Medical Sciences,
    Volume 17,Issue 2,
    2023,
    Pages 135-138,
    ISSN 1815-9346,
    10.59218\makrjms.2023.135.138,
    (https://makhillpublications.co/view-article.php?doi=10.59218\makrjms.2023.135.138)
    Abstract: <p style="text-align:justify">Nutritional anemia is most prevalent in the Indian population which may predispose to many health ailments. To observe the effects of oral ferrous sulphate 100 mg tablets with folic acid 100 mcg twice daily and injection vitamin B12 (cobalamin) 1000 mcg weekly in patients with severe anemia. A prospective interventional study was conducted in Vels Medical College and Hospital for the period of one year from May 2022 to April 2023 on 50 patients, attending outpatient clinic of Vels Medical College and Hospital, Tiruvallur District, Tamil Nadu. A thorough history followed by clinical examination were carried out and patients were given oral ferrous sulphate 100 mg with folic acid 100 mcg tablets twice daily with injection B12 weekly was given after estimation of baseline hemoglobin level. Estimation of hemoglobin level was done at 4 weeks time interval. All adverse events following the study was noted and asked for compliance, tolerance and side effects. Improvement in the hemoglobin levels from 6.2 g dL&oline;<sup>1</sup> from enrollment level to 8.7 g dL&oline;<sup>1</sup> after one month of treatment was noted which was statistically significant with minor adverse effects. The combination of oral ferrous sulphate 100 mg parenteral Vitamin B12 and folic acid may provide an efficient, effective, safe and practical option to treat severely anemic patients, especially in resource-poor settings.</p>

    Keywords: Nutritional anemia; folic acid; methylcyanocobalamin ferrous sulphate