S. Touahri , M. Babes , H. Kateb , H. Labar , Design of Experiment (DOE) In the Improvement of the Technico-economic Indexes of H.V. Networks, Asian Journal of Information Technology, Volume 5,Issue 6, 2006, Pages 647-651, ISSN 1682-3915, ajit.2006.647.651, (https://makhillpublications.co/view-article.php?doi=ajit.2006.647.651) Abstract: The goal of this study, is to present the advantages of the design of experiments method, that consist in establishing the link between the studied physical sizes (objects functions) and their sources of variation (factors) of any process. so we had applied this method to the analysis of the powers flow process in a H.V. network with two levels of voltages while using a fractional factorial plan 2. The equation of regression (models) establish, explain a simple and efficient way, the experimental results that have been gotten on a P.4 by a software that we elaborated and perfected by Matlab version 6.5. The present work opens other multi-dimensional optimization perspectives in the electrical networks that prove to be until at the time, very complex. Keywords: Design expériment;objects functions;power flow;statistic;modélization