Kazuya  Edamura, Kimiyoshi  Okano, Taro  Kimura, Ryouichi  Suzuki, 
    Isoflurane-Sparing Effect of Maropitant in Cats Undergoing
Ovariohysterectomy,
    Journal of Animal and Veterinary Advances,
    Volume 17,Issue 3,
    2018,
    Pages 82-86,
    ISSN 1680-5593,
    javaa.2018.82.86,
    (https://makhillpublications.co/view-article.php?doi=javaa.2018.82.86)
    Abstract: Maropitant exerts antiemetic effects and is also effective in reducing the inhalational anesthetic
requirement. In this study, 20 Japanese domestic cats that were brought to a private animal hospital to be
spayed were divided into two groups: one group was administered a combination of Maropitant and
Buprenorphine (MAR group, n = 10) and the other group was administered saline solution and buprenorphine
(control group, n = 10). In all cases, ovariohysterectomy was performed under general anesthesia using
isoflurane. The isoflurane concentration was measured in both groups at the following stages: at 15 min after
initiating inhalational anesthesia (T<sub>0</sub> ), during skin incision (T<sub>1</sub> ), left ovary retraction stimulation (T<sub>2</sub>), right ovary
retraction stimulation (T<sub>3</sub>), uterus retraction stimulation (T<sub>4</sub>), start of abdominal closure (T<sub>5</sub>) and start of skin suture (T<Sub>6</Sub>). The isoflurane requirements in the MAR group were significantly lower than those in the control group at T<sub>4</sub> -T<Sub>6</Sub> (p&lt;0.05) and the requirement decreased at T<Sub>6</Sub> by approximately 5.5%. 
These results suggest that maropitant might have an isoflurane-sparing effect in cats undergoing
ovariohysterectomy.
    Keywords: Cat;isoflurane;laparotomy;maropitant;ovariohysterectomy;concentration;administered