Fahad Abdullah  Al-Hizab, Mohammed Salem  Moqbel, Seif Mustafa  Barakat, 
    Pathological Studies of Various Levels of Dietary
<i>Momordica charantia</i> on Wistar Rats,
    Journal of Animal and Veterinary Advances,
    Volume 16,Issue 2,
    2017,
    Pages 43-47,
    ISSN 1680-5593,
    javaa.2017.43.47,
    (https://makhillpublications.co/view-article.php?doi=javaa.2017.43.47)
    Abstract: The study aimed to evaluate the pathological, haematological and biochemical effects of various
levels of dietary<i> Momordica charantia</i> (MC) in male Wistar rats.<i> Momordica charantia</i> (MC) is claimed to
have several medicinal properties and is used as a traditional medicine for the treatment of a wide variety of
disorders. The fruits of MC was fed to rats at 2, 5 and 10% of the standard diet for a period of 3 months.
Administration of MC fruits at 2 and 5% was not toxic to rats. However, focal cellular swelling and individual
cell necrosis of hepatocytes as well as degenerative changes in the renal tubules associated with interstitial
nephritis were observed in rats fed with a diet containing 10% MC. These histopathological changes were
accompanied clinically by alteration of serum Aspartate aminotransferase (AST), Alanine aminotransferase
(ALT), Alkalin Phosphatase (ALP), BUN, creatinine and uric acids. No significant changes were observed in
hematological values in all groups.
    Keywords: Clinicopathology;histopathology;hepatotoxicity;Momordica charantia;nephrotoxicity