Li-Li  Zhao, Na  Tang, Yuan-Yuan  Zhang, Xiao-Hui  Yu, Guo-Zhong  Zhang, 
    Safety Assessment of a Turkey Herpes Virus Vector Newcastle Disease Vaccine in Chickens,
    Journal of Animal and Veterinary Advances,
    Volume 13,Issue 14,
    2014,
    Pages 897-900,
    ISSN 1680-5593,
    javaa.2014.897.900,
    (https://makhillpublications.co/view-article.php?doi=javaa.2014.897.900)
    Abstract: A recombinant Herpes Virus of Turkeys (HVT) vaccine expressing the key protective antigen of Newcastle Disease Virus (NDV) could facilitate in the prevention and control of both Marek&#146;s Disease Virus (MDV) and NDV infections. The VECTORMUNE<SUP>&reg;</SUP> HVT NDV vaccine is a recombinant vaccine in which the <I>F</I> gene of a NDV lentogenic strain has been inserted into the HVT genome. In the current study, this vaccine was assessed for its safety in chickens. Based on clinical observations, gross pathological examinations, histopathological examinations, virus shedding and tissue distribution, the VECTORMUNE<SUP>&reg;</SUP> HVT NDV vaccine was determined to possess a high level of safety in chickens.
    Keywords: safety assessment;F gene;Newcastle disease virus;vaccine;HVT vector