Guoxin  Ni, Yao  Wu, Bin  Tong, Kaifeng  Wu, Seiki  Sasaki, Youji  Muramatsu, Takeshi  Ohta, Hiroyuki  Kose, Takahisa  Yamada, Dong  Zhang, 
    Association of Single Nucleotide Polymorphism in <I>IRS1</I> Gene with Growth-Related Trait in Japanese Black Beef Cattle,
    Journal of Animal and Veterinary Advances,
    Volume 13,Issue 1,
    2014,
    Pages 37-40,
    ISSN 1680-5593,
    javaa.2014.37.40,
    (https://makhillpublications.co/view-article.php?doi=javaa.2014.37.40)
    Abstract: Growth performance as well as marbling is the main breeding 
  objectives in Japanese Black cattle, the major beef breed in Japan. The Insulin 
  Receptor Substrate 1 (<I>IRS1</I>) gene is reported to be associated with insulin 
  resistance and birth weight in human and has been previously shown to be located 
  within genomic region of a quantitative trait locus for growth-related trait. 
  The previous study detected a Single Nucleotide Polymorphism (SNP), referred 
  to as g.120947716T&gt;C in the promoter region of the <I>IRS1</I> gene which 
  exhibited significantly different allelic distribution between Japanese Black 
  sires with extremely high predicted breeding value and the sires with extremely 
  low one for Carcass Weight (CWT) and Rib Thickness (RT) in a preliminary study. 
  In this study, researchers analyzed the effect of the IRS1 g.120947716T&gt;CSNP 
  genotypes on the growth-related carcass trait in Japanese Black beef cattle. 
  The SNP was associated with CWT and RT (p = 0.030 and 0.005, respectively) in 
  experiment using 100 Japanese Black sires. This finding suggests possible effect 
  of the g.120947716T&gt;C on the growth-related trait in Japanese Black beef 
  cattle. The IRS1 SNP may be useful for effective marker-assisted selection to 
  increase the beef productivity in Japanese Black beef cattle.
    Keywords: Association;beef cattle;growth-related trait;IRS1;Japanese Black breed;single nucleotide polymorphism