Hyun-Soo  Kim, Youn Wha  Kim, 
    Serum mRNA Levels of Interleukin-1α and Interleukin-1β Increase upon Exposure to Intermittent Hypoxia,
    Journal of Animal and Veterinary Advances,
    Volume 12,Issue 8,
    2013,
    Pages 888-891,
    ISSN 1680-5593,
    javaa.2013.888.891,
    (https://makhillpublications.co/view-article.php?doi=javaa.2013.888.891)
    Abstract: Intermittent Hypoxia (IH) is the most common pattern of hypoxic 
  exposure. The pro-inflammatory cytokine Interleukin (IL)-1 is present in the 
  tissues or systemic circulation in many inflammatory conditions. Although, some 
  earlier studies have shown that hypoxia enhanced the production of pro-inflammatory 
  cytokines, the effects of IH on the expression of <I>IL-1</I> gene have not 
  been investigated yet. The aim of this study was to examine whether IH affects 
  the mRNA expression levels of two IL-1 molecules, IL-1&#945; and IL-1&#946; 
  in rat serum. To obtain IH, 11 male Sprague-Dawley rats were placed in a hypobaric 
  chamber (282 mm Hg, 30 min day<SUP>-1</SUP>, 14 days). The mRNA expression levels 
  of IL-1&#945; and IL-1&#946; in serum were determined using quantitative real-time 
  RT-PCR. All of the rats exposed to IH exhibited significantly higher levels 
  of IL-1 mRNA expression than the normoxic control rats. Exposure to IH resulted 
  in 6.0 and 6.3 fold increases in the amount of IL-1&#945; and IL-1&#946; mRNA 
  when compared to that of the control group (p&lt;0.001, both). Researchers demonstrated 
  that the serum levels of IL-1&#945; and IL-1&#946; mRNA were significantly increased 
  in rats following 14 days of exposure to IH. The result suggests that IH has 
  a positive effect on transcription of the <I>IL-1&#945;</I> and <I>IL-1&#946;</I> 
  genes.
    Keywords: Intermittent hypoxia;serum;interleukin-1a;interleukin-1B;rat