Jianzhen  Lv, Zijie  Wang, Li  Zhang, Hai-Lian  Wang, Yuande  Liu, Chunyang  Li, Jiagang  Deng, Yi-Wang  , Jin-Ku  Bao, 
    Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both <I>in vitro</I> and <I>in vivo</I>,
    Journal of Animal and Veterinary Advances,
    Volume 12,Issue 3,
    2013,
    Pages 352-359,
    ISSN 1680-5593,
    javaa.2013.352.359,
    (https://makhillpublications.co/view-article.php?doi=javaa.2013.352.359)
    Abstract: Mangiferin, a C-glucosylxanthone (1, 3, 6, 7-tetrahydroxyxanthone-C2-&#946;-D-glucoside) purified from plant sources was shown to have <I>in vitro</I> growth-inhibitory and apoptosis-inducing activity against MCF-7 cells and it also possessed anti-tumor property on MCF-7 xenograft mice <I>in vivo</I>. Mangiferin triggered G<SUB>2</SUB>/M phase cell-cycle arrest via down-regulating cdc2-cyclinB1 singling pathway and induced apoptotic cell death through inhibiting PKC-NF&#954;B pathway in human breast carcinoma MCF-7 cells. In addition, mangiferin had anti-cancer effects <I>in vivo</I> and it could decrease the volume and weight of subcutaneous tumor mass obviously as well as expanded lifespan of xenograft mice. With the molecular mechanisms of mangiferin-induced anti-tumor activities were gradually clarified, traditional Chinese medicine would become potential anti-neoplastic drugs in future cancer therapeutics.
    Keywords: Mangiferin;cdc2-cyclinB1 singling pathway;PKC-NFkB pathway;drugs;tumor