Honglin  Liu, ChunLei  Song, XiuXing  Wang, Xuguang  Wang, Xueshan  Ma, Jun  Zhang, BeiBei  Gao, 
    Abnormal Follicle Development in GGPPS Conditional Knockout Mice,
    Journal of Animal and Veterinary Advances,
    Volume 12,Issue 3,
    2013,
    Pages 323-329,
    ISSN 1680-5593,
    javaa.2013.323.329,
    (https://makhillpublications.co/view-article.php?doi=javaa.2013.323.329)
    Abstract: GGPPS is a member of prenyl transferase family catalyzing the synthesis of GGPP (Geranylgeranyl diphosphate) from Farnesyl diphosphate (FPP) and Isopentenyl diphosphate (IPP). Using cre/loxp system, researchers got oocyte specific knockout ggpps mice. Mutation of ggpps resulted in abnormality of follicular development, granulosa cell premature luteinization, theca cell hypertrophy and multi-oocyte follicles. Interaction of oocyte and granulosa cell was also changed. Oocyte-specific knockout of ggpps mice was acquired. Follicles grew abnormally in ggpps mutation mice. Interaction of oocyte and granulosa cell was also changed.
    Keywords: ggpps;conditional knockout;follicular development;multi-oocyte follicles;IPP