Wang-Liang , Jin Ming-Wu, Zhang Weiwei, Zhang Yong-Gen,
Studies on the Pharmacokinetics of Melamine in Dairy Goat,
Journal of Animal and Veterinary Advances,
Volume 12,Issue 14,
2013,
Pages 1217-1219,
ISSN 1680-5593,
javaa.2013.1217.1219,
(https://makhillpublications.co/view-article.php?doi=javaa.2013.1217.1219)
Abstract: This experiment was conducted to study the pharmacokinetics
of melamine in dairy goat. A single intravenous administration of the melamine
at the dose of 6.13 mg kg-1 B.W. to 6 dairy goats. Blood samples
were collected at different intervals after administration and concentrations
of melamine were determined by HPLC Method. The plasma concentration-time data
of melamine was analyzed by Pharmaceutical 3P97. The results showed that two-compartment
open model was the optimum one of melamine in the dairy goats. The main pharmacokinetic
parameters were as follows: Vd was (0.03±0.01) L kg-1,
t1/2β was (3.64±0.02) h, AUC was (41.96±0.52)
μg h mL-1, Cl was (0.14±0.01) L kg-1 h-1.
These results indicated that the distribution of melamine in dairy goat was
limit and the elimination of melamine was rapid.
Keywords: Melamine;pharmacokinetics;dairy goat;HPLC;goat