Ji-Yu  Zhang, Xu-Zheng  Zhou, Bing  Li, Ya-Jun  Yang, Xiao-Juan  Wei, Jian-Rong  Niu, Jian-Yong  Li, Jin-Shan  Li, Xi-Wang  Liu, 
    Therapeutic and Persistent Efficacy of Doramectin Against Nematode in Swine Infected Naturally in China,
    Journal of Animal and Veterinary Advances,
    Volume 11,Issue 24,
    2012,
    Pages 4684-4688,
    ISSN 1680-5593,
    javaa.2012.4684.4688,
    (https://makhillpublications.co/view-article.php?doi=javaa.2012.4684.4688)
    Abstract: The purpose of this study was to evaluate the treatment efficacy 
  of 1% doramectin injection against nematode in swine infected naturally in China 
  and determine dosage regimen of doramectin in swine. A controlled clinical study 
  was conducted on 200 swine infected with nematode naturally in Lanzhou. The 
  tested groups included doramectin 400, 300 and 150 &#956;g kg<SUP>-1</SUP> by 
  IM, ivermectin 300 &#956;g kg<SUP>-1</SUP> by SC as drug control group and blank 
  control group. The results showed the efficacy against nematode of high dosage 
  doramectin (400 &#956;g kg<SUP>-1</SUP>) was significantly difference from middle 
  and low dosage group (p&lt;0.05) and was significantly difference from control 
  ivermectin group (p&lt;0.01). The persistent period of nematocidal with high, 
  middle and low dosage were 28, 28 and 21 days, respectively. The body weight 
  gain of high, middle dosage doramectin and ivermectin group were significantly 
  difference from the low dosage doramectin and untreated control (p&lt;0.05 and 
  p&lt;0.01). So, the recommended dosage regimen of doramectin against swine&#146;s 
  nematode was 300 &#956;g kg<SUP>-1</SUP> body weights by IM for once administration 
  of medicine.
    Keywords: Doramectin;nematode;swine;therapeutic efficacy;China