Takahisa  Yamada, Bin  Tong, Kaifeng  Wu, Seiki  Sasaki, Youji  Muramatsu, Takeshi  Ohta, Hiroyuki  Kose, Hideaki  Yamashiro, Yanru  Zhang, 
    Possible Effects of Single Nucleotide Polymorphism in <I>CDC10</I>, <I>IRS1 
  </I>and <I>MFN2</I> Genes on Growth-Related Traits in Japanese Black Beef Cattle,
    Journal of Animal and Veterinary Advances,
    Volume 11,Issue 24,
    2012,
    Pages 4536-4539,
    ISSN 1680-5593,
    javaa.2012.4536.4539,
    (https://makhillpublications.co/view-article.php?doi=javaa.2012.4536.4539)
    Abstract: Growth performance as well as marbling is the main breeding 
  objectives in Japanese Black cattle, the major beef breed in Japan. Researchers 
  have recently reported that existence of Single Nucleotide Polymorphisms (SNPs), 
  g.63629097G&gt;C, g.120947716T&gt;C and g.38437771C&gt;T in the promoter regions 
  of the septin 7 (CDC10), the insulin receptor substrate 1 (<I>IRS1</I>) and 
  the mitofusin 2 (<I>MFN2</I>) genes, respectively in Japanese Black beef cattle 
  population. The CDC10 is known to be involved in cellular proliferation and 
  the IRS1 is reported to be associated with insulin resistance and birth weight. 
  The 2 genes have been earlier shown to be located within genomic regions of 
  quantitative trait loci for growth-related traits. Thus, the <I>CDC10</I> and 
  <I>IRS1</I> genes were considered as positional functional candidates for the 
  gene responsible for growth performance. In addition, the MFN2 is known to play 
  a role in energy balance through mitochondrial fusion, so the <I>MFN2</I> gene 
  was considered as functional candidate. In this study, researchers analyzed 
  the possible effects of the 3 SNPs on the growth-related carcass traits: Carcass 
  Weight (CWT), Rib Thickness (RT), Rib Eye Area (REA) and Subcutaneous Fat Thickness 
  (SFT) in Japanese Black beef cattle. The g.63629097G&gt;C and g.120947716T&gt;C 
  SNPs in the CDC10 and IRS1, respectively, exhibited significantly different 
  allelic distribution between Japanese Black sires with extremely high predicted 
  breeding value and the sires with extremely low one for CWT and RT but not for 
  the others. The g.38437771C&gt;T SNP in the MFN2 had significantly different 
  allelic distribution for RT. These findings suggest possible effects of the 
  g.63629097G&gt;C, g.120947716T&gt;C and g.38437771C&gt;T SNP on the growth-related 
  trait in Japanese Black beef cattle. The SNPs in the <I>CDC10</I>, <I>IRS1</I> 
  and <I>MFN2</I> genes may be useful for effective marker-assisted selection 
  to increase the beef productivity in Japanese Black beef cattle.
    Keywords: Association analysis;CDC10;growth-related carcass trait;IRS1;Japanese Black beef cattle;MFN2;single nucleotide polymorphism