Ming-Ren  Ma, Yan  Wei, Xiao-Hui  Wang, Qing-Hua  Jia, Ye-Wei  Chang, Yu  Tang, Mei-Liang  Wang, Ling  Hui, Xiao-Qin  Ha, 
    Analysis of Codon Contribution Between the <I>Pestivirus</I> Genus and Their Natural Hosts,
    Journal of Animal and Veterinary Advances,
    Volume 11,Issue 21,
    2012,
    Pages 3999-4004,
    ISSN 1680-5593,
    javaa.2012.3999.4004,
    (https://makhillpublications.co/view-article.php?doi=javaa.2012.3999.4004)
    Abstract: Pestiviruses including Classical Swine Fever Virus (CSFV), Bovine Viral Diarrhea Virus (BVDV) and Border Disease Virus (BDV) can cause serious livestock diseases. The genetic characteristics between the three viruses and their hosts were analyzed by the Relative Synonymous Codon Usage value (RSCU) based on principle component analysis method. To compare with the overall codon usage between the three pestiviruses and their hosts, the overall codon usage of CSFV is away from BVDV and BDV and some strains of CSFV are strongly separated from others strains. These results indicate that although a strong mutation pressure from the three RNA viruses takes part in these viruses&#146; evolution by the alternation of synonymous codons, translation selection from their hosts on the synonymous codon usage pattern of the viral whole coding sequences should not be ignored. Moreover, the codon distribution of the three pestiviruses relatively adapts to the overall codon usage pattern of their hosts. The general codon usage patterns of the three pestiviruses are the equilibrium of mutation pressure from virus and translation selection from host.
    Keywords: mutation pressure;the overall codon usage;genetic characteristic;Pestivirus;translation selection;hosts