Hiroshi  Murakami, Fumiki  Morimatsu, Takahisa  Yamada, Seiki  Sasaki, Shin  Sukegawa, Youichi  Takahagi, Mitsuo  Morita, Tatsuo  Fujita, 
    Possible Association of Single Nucleotide Polymorphism in <I>Titin</I> Gene with Growth-Related Trait in Japanese Black Beef Cattle,
    Journal of Animal and Veterinary Advances,
    Volume 10,Issue 19,
    2011,
    Pages 2603-2606,
    ISSN 1680-5593,
    javaa.2011.2603.2606,
    (https://makhillpublications.co/view-article.php?doi=javaa.2011.2603.2606)
    Abstract: Growth performance as well as marbling is the main breeding objectives in Japanese Black cattle, the major beef breed in Japan. The researchers have recently reported that a Single Nucleotide Polymorphism (SNP), referred to as g.231054C&gt;T in promoter region of the <I>Titin</I> (<I>TTN</I>) gene was associated with marbling in Japanese Black beef cattle with the T allele being associated with a high level of marbling. The TTN is known to be involved in myofibrillogenesis and has been previously shown to be located within genomic region of a quantitative trait locus for rib eye area. Thus, the TTN was considered as a positional functional candidate for the gene responsible for growth performance. In this study, the researchers analyzed the effect of the TTN g.231054C&gt;T SNP genotypes on the growth-related carcass traits in Japanese Black beef cattle. The SNP was marginally associated with rib eye area in two experiments using 101 sires (p = 0.067) and 820 paternal half-sib progeny steers from 3 sires homozygous for C allele at the g.231054C&gt;T (p = 0.090) in Japanese Black beef cattle. These findings suggest possible effect of the g.231054C&gt;T on the growth-related trait in Japanese Black beef cattle. The TTN SNP polymorphism may be useful for effective marker-assisted selection to increase the beef productivity in Japanese Black beef cattle.
    Keywords: beef cattle;Association;growth-related trait;Japanese black breed;single nucleotide polymorphism;TTN