Daichi  Oikawa, Yoriko  Akimoto, Yurika  Mizobe, Shoichiro  Tsuyama, Mitsuhiro  Furuse, 
    Functions of CLA and ARA for Prevention of CCl<SUB>4</SUB>-Induced Fatty Liver in Mice,
    Journal of Animal and Veterinary Advances,
    Volume 9,Issue 22,
    2010,
    Pages 2854-2858,
    ISSN 1680-5593,
    javaa.2010.2854.2858,
    (https://makhillpublications.co/view-article.php?doi=javaa.2010.2854.2858)
    Abstract: Oral administration of carbon tetrachloride (CCl<SUB>4</SUB>) induces acute hepatitis while Prostaglandins (PGs) are proposed to attenuate liver injury. Conjugated Linoleic Acid (CLA) influences the synthesis of PGs and Arachidonic Acid (ARA) is a precursor of PGs. Therefore, whether CLA or ARA attenuates the hepatitis induced by CCl<SUB>4</SUB> was investigated in mice. Male mice (age, 8 week) were given commercial diet and combinations of paraffin or CCl<SUB>4</SUB> solution with or without CLA or ARA oil were orally administered. Food intake and body weight were significantly reduced in the CCl<SUB>4</SUB> group. Although, no significant changes in liver weight were observed, liver triacylglycerol contents in the CCl<SUB>4</SUB>+CLA and CCl<SUB>4</SUB>+ARA groups were markedly higher than those in groups other than the CCl<SUB>4</SUB> group. Plasma AST and ALT levels were unusually elevated after CCl<SUB>4</SUB> administration irrespective of oil treatment. CCl<SUB>4</SUB>+ARA treatment greatly increased PGE<SUB>2</SUB> content in the liver and followed by CCl<SUB>4</SUB>+CLA treatment. In conclusion, co-administration of CLA and ARA enhanced liver PGE<SUB>2</SUB> levels after CCl<SUB>4</SUB> treatment but acute hepatitis was not attenuated.
    Keywords: Conjugated linoleic acid;arachidonic acid;mice;carbon tetrachloride;hepatitis;prostaglandin E2