G.  Ajitkumar, R.  Praseeda, K.  Rajankutty, P.C.  Alex, 
    Comparative Efficacy of High vs. Low Dose Cabergoline Treatment Regimen in Inducing Fertile Oestrus in Anoestrous Dogs,
    Journal of Animal and Veterinary Advances,
    Volume 9,Issue 12,
    2010,
    Pages 1735-1738,
    ISSN 1680-5593,
    javaa.2010.1735.1738,
    (https://makhillpublications.co/view-article.php?doi=javaa.2010.1735.1738)
    Abstract: Twenty four bitches in anoestrus for &gt;6 months from the last heat with a serum progesterone level &gt;1 ng mL<SUP>-1</SUP> were divided into two groups and subjected to oestrus induction trials using anti-prolactin drug cabergoline at 5 and 1 &#956;g kg<SUP>-1</SUP> body weight respectively, once daily orally for 20 consecutive days. The mean serum progesterone level among them during anoestrus was found to be 0.56&plusmn;0.01 ng mL<SUP>-1</SUP>. Out of 12 animals treated in each group, 10 (83.34%) in group I and 9 (75%) in group II responded by evincing proestrual bleeding. The mean (&plusmn;SEM) time taken from initiation of treatment to onset of proestrual bleeding in Groups I and II was 13.50&plusmn;0.50 (p&lt;0.01) and 21.89&plusmn;0.86 days, respectively. About 25% of animals treated with high dose cabergoline exhibited side effects as against none with low dose. The mean (&plusmn;SEM) duration of proestrus and oestrus in the treatment groups was 8.70&plusmn;0.30 (p&lt;0.05) and 9.56&plusmn;0.38 days and 8.20&plusmn;0.29 and 8.33&plusmn;0.24 days, respectively. The conception rate in relation to the number of animals responding to oestrus induction in the treatment groups was 90 and 88.89%, respectively. The mean (&plusmn;SEM) gestation length calculated from the last breeding date and litter size in the treatment groups were 62&plusmn;0.41 and 62.88&plusmn;0.49, 6.44&plusmn;0.29 and 6.13&plusmn;0.23, respectively.
    Keywords: Bitch;infertility;anoestrus;oestrus induction;cabergoline;conception rate