Asim Kart  , Stanley Leon Vanhooser  , Subbiah Sangiah  , 
    Oral Administration of Lasalocid Causes Peripheral Neuropathy in Sprague Dawley Rats:Effect of Water Salinity on Lasalocid-induced Peripheral Neuropathy,
    Journal of Animal and Veterinary Advances,
    Volume 4,Issue 8,
    2005,
    Pages 719-722,
    ISSN 1680-5593,
    javaa.2005.719.722,
    (https://makhillpublications.co/view-article.php?doi=javaa.2005.719.722)
    Abstract: Lasalocid toxicity was associated with several neurotoxicity cases in animal species. Incidence of lasalocid neurotoxiciy shows a higher rate in chickens during heat stress with increased water salinity. In the present study, It studied the effect of lasalocid with or without 0.9 % NaCl in male Sprague Dawley. The rats were given 0, 10, 20, 40 mgkgG of lasalocid two times a day for 3 days with or without 0.9 % saline in the 1 drinking water. Rats showed ataxia in the 20 and 40 mgkgG dose groups with higher death rate in group 1 receiving 40 mgkgG of lasalocid. Dietary salt did not affect ataxia induced by lasalocid. While the optimum dose 1 to produce ataxia (without high mortality) appears to be 20 mgkgG of lasalocid, increasing salinity of water has 1 no effect on the neurotoxicity of lasalocid.
    Keywords: Lasalocid;ataxia;neurotoxicity;heat stress;salinity