TY  - JOUR
T1  - Hepatoprotective Activity of Methanol Extracts from Artemisia Sieberi Besser
(<i>A. Herba-alba</i>) Against Ethanol Induced Hepatic Damage Rats
AU - Mansi, Kamal AU - Aburjia, Talal AU - Abu-Albasal, Maryam 
JO  - Research Journal of Medical Sciences
VL  - 13
IS  - 5
SP  - 102
EP  - 108
PY  - 2019
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2019.102.108
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2019.102.108
KW  - Artemisia sieberi Besser (A. Herba-alba)
KW  -hepatotoxicity
KW  -Hepatoprotective effect
KW  -liver enzymes
KW  -hematological parameters
KW  -methanol
AB  - Hepatoprotective effect of methanolic extracts from Artemisia sieberi Besser aerial parts was
investigated against ethanol induced-acute hepatotoxicity in experimental rats. They were divided into four
groups with 20 rats in each one. Group I: non-hepatotoxic rats received only the vehicle (0.5 mLkg<sup>-1</sup> body
weight) and served as a control group. Group II: rats were orally administered with 2 mL ethanol every alternate
day for 30 days to generate hepatotoxity. Groups III: hepatotoxic rats treated with 25 mgkg<sup>-1</sup> silymarin drug.
Group IV: hepatotoxic rats treated with 100 mgkg<sup>-1</sup> methanol extracts of Artemisia sieberi Besser. All
treatments were orally administrated by gavage for 30 consecutive days. At the end of the experiment, the rats
of all groups were sacrificed and the excised liver was weighed. Liver enzyme markers (SGOT, SGPT, ALP),
total protein, albumin, bilirubin (direct and total) and lipid profile were measured from blood serum samples.
As well, the analysis of the CBC was performed on whole blood samples. Results revealed significant increase
of the liver enzyme markers, total and direct bilirubin and lipid profile in the hepatotoxic group. Conversely,
significant reduction in the liver weight, levels of total protein, albumin and parameters of the CBC panel was
also noticed as compared with the control group. However, treatment with methanol extracts significantly
enhanced the liver weight and brought back the altered levels of hematological and biochemical markers to the
nearby normal levels, compared to those detected in the control and silymarin treated groups. It is concluded
from the results of the present study that the methanol extracts of Artemisia sieberi Besser aerial parts possesses
hepatoprotective activity against ethanol induced hepatotoxicity in rats.
ER  -