TY  - JOUR
T1  - The Status of Hepatitis G/C Virus among HIV Positive Patients and
Effects of GBV-C on the Progress of HIV Infection
AU - Pirouzi, Aliyar AU - Afkari, Rouhi AU - Taheri, Abdollah AU - Delkhosh, Yaghoob AU - Sekhavati, Eghbal 
JO  - Research Journal of Medical Sciences
VL  - 10
IS  - 3
SP  - 91
EP  - 96
PY  - 2016
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2016.91.96
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2016.91.96
KW  - Human Immunodeficiency Virus (HIV)
KW  -GBV-C
KW  -HCV
KW  -cell counts
KW  -RT-PCR
AB  - Individuals infected with the Human Immunodeficiency Virus (HIV) are often co-infected with other pathogens in particular hepatitis viruses. HCV and GBV-C are blood-borne viruses that are highly prevalent among HIV/AIDS patients. The aim of this study was to evaluate the presence of hepatitis G virus (GBV-C) among HIV positive patients and its effect on the progress of HIV disease. One hundred and fifty HIV infected patients (92 men and 58 women) were included in this study. Patients were categorized into four different high-risk groups: intravenous drug users (n = 48), hemophiliacs (n = 45), homosexuals (n = 32) and heterosexuals (n = 25). RNA was extracted from 100 &mu;L of serum or plasma using RNX plus kit. Reverse Transcription Polymerase Chain Reaction (RT-PCR) and nested PCR were used to detect GBV-C-RNA and HCV-RNA. GBV-C-RNA and HCV-RNA were found in 26.66 and 30% of patients, respectively. The prevalence of GBV-C for intravenous drug users, hemophiliacs, homosexuals, heterosexuals those with history of kidney disease and patients with a history of liver disease was 31.25, 28.88, 21.88, 20, 28.58 and 25%, respectively. Data show that within 4 years, CD<sup>+4</sup> cell counts increased from 398-502 cells/mm<sup>3</sup> while HIV-RNA load decreased to 2.1&plusmn;0.7 log<sub>10</sub> copies/mL and HGV-RNA load increased to 2.5&plusmn;2.08 log<sub>10</sub> copies/mL. The prevalence of GBV-C and HCV in HIV infection variy in different groups. Our study shows a significant relationship between co-infection with GBV-C and HIV since it slows the progression of HIV and liver diseases in 4 years after being infected.
ER  -