TY  - JOUR
T1  - Evaluation of Protective Effects of N-Acetyl Cysteine and Vitamin C on
Perioperative Renal Function in High-Risk Patients Undergoing
Coronary Artery Surgeries, a Randomized Clinical Trial
AU - Karami, Ali AU - Soltani, Saeed Reza AU - Vatankhah, Pooya AU - Akhlagh, Seyd Hedayatallah AU - Masjedi, Mansoor AU - Shafa, Masih 
JO  - Research Journal of Medical Sciences
VL  - 10
IS  - 6
SP  - 711
EP  - 715
PY  - 2016
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2016.711.715
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2016.711.715
KW  - Antioxidants
KW  -coronary artery bypass
KW  -acetylcysteine
KW  -renal insufficiency
KW  -ascorbic acid
AB  - Perioperative renal failure is one of the major complications following coronary artery surgeries,
leading to increased morbidity and mortality rates in patients; necessitating renal replacement therapy and
longer hospital and ICU stay. Considering the antioxidative effects of N-Acetyl Cysteine (NAC) and vitamin
C in decreasing inflammatory factors, this study was designed to evaluate and compare the protective effects
of these two agents on renal function of high-risk patients undergoing coronary artery surgeries. This study
was a randomized clinical trial research. Ninety patients undergoing cardiac bypass surgery, who were
considered as high-risk for postoperative renal failure, were randomized into 3 groups. Group A received NAC,
group B received NAC plus vitamin C and group C received Dextrose water 5% as placebo. The agents were
administered during and 12 and 24 h after the operation. Serum creatinine levels one day before the operation
and also on 1st, 2nd and 3rd days after the operation were recorded and compared. The results revealed no
significant differences in serum creatinine levels between the three groups in any of the evaluated days. Based
on the results of our study, administration of NAC or its combination with vitamin C does not affect the
outcome of renal function in high-risk patients undergoing cardiac bypass surgery.
ER  -