TY  - JOUR
T1  - Polyphenolics-Rich <I>Psidium guajava</I> Budding Leaf Extract CanReverse Diabetes-Induced Functional Impairment of Cavernosal Smooth Muscle Relaxation in Rats
AU - Liu, Chia-Hung AU - Peng, Chiung-Chi AU - Peng, Chiung-Huei AU - Hsieh, Chiu-Lan AU - Chen, Kuan-Chou AU - Peng, Robert Y. 
JO  - Research Journal of Medical Sciences
VL  - 4
IS  - 1
SP  - 25
EP  - 32
PY  - 2010
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2010.25.32
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2010.25.32
KW  - Diabetes mellitus
KW  -erectile dysfunction
KW  -Psidium guajava
KW  -corpus cavernosum
AB  - Diabetes Mellitus (DM) related Advanced Glycation End products (AGEs) are considered to induce functional impairment of cavernosal smooth muscle relaxation and cause Erectile Dysfunction (ED). We used rats to examine the <I>in vitro</I> effects of <I>Psidium guajava</I> L. (Myrtaceae) budding leaf extract (PE) on pharmacological  relaxation  of  corpus  cavernosum  smooth  muscle strips obtained from diabetic rats. After 8 weeks, the mean glycosylated haemoglobin (HbA1c), serum cholesterol and triglyceride concentrations were significantly higher in the non-PE diabetic than in the age-matched control animals. Interestingly, in diabetic animals fed PE, serum cholesterol and triglyceride levels were significantly lower than in their peers given a standard diet. The administration of PE to diabetic animals for 8 weeks reversed the expected impaired relaxation response and nitric oxide production in cavernosal smooth muscle exposed to acetylcholine or electrical field stimulation. The administration of PE to rats with 8 weeks of uncontrolled diabetes reverses DM-induced harmful effects on vascular smooth muscle.
ER  -