TY  - JOUR
T1  - Halofantrine (Anti-Malaria) Toxicity in Wister Rats: Biochemical Evaluation of Hepatic Dysfunction
AU - , H.U. Nwanjo AU - , N.J.C. Okolie AU - , G. Oze AU - , M.C. Okafor AU - , D. Nwosu AU - , C. Ajero AU - , B. Anyaehie AU - , G.C. Uloneme AU - , C.J. Njoku AU - , P. Nwamkpa 
JO  - Research Journal of Medical Sciences
VL  - 1
IS  - 2
SP  - 102
EP  - 105
PY  - 2007
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2007.102.105
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2007.102.105
KW  - Halofantrine
KW  -hepatic dysfunction
KW  -toxicity
KW  -AST
KW  -ALP
AB  - Halofantrine is a phenanthrene methanol, belonging to the aryl-amino alcohol family, which is widely prescribed for the treatment of infections with chloroquine-resistant strains of <I>Plasmodium falciparium</I>. This study examined biochemical evaluation of hepatic dysfunction as a result of halofantrine toxicity in Wistar rats. Various concentrations of halofantrine (30, 60 and 90 mg kg <SUP>1</SUP> were administered to the three groups of Wistar rats. The fourth group of animals received distilled water (control). The body weight changes and the relative weight of the liver were measured. The serum hepatospecific markers such as Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP) activities and serum total bilirubin level were also estimated. The halofantrine  treated groups had a significant increase in the relative weight of their livers (p< 0.05) when compared with control. There was also significant increase in all the enzymes and total bilirubin (p< 0.05) when  compared  with control. The results indicated that halofantrine might have hepatotoxic effect in Wistar rats.
ER  -