TY - JOUR T1 - To Assess the Role of Vaginal Micronised Progesterone as a Tocolytic Therapy in Arrested Preterm Labour AU - Meena, Anita AU - Jain, Renu AU - Yadav, Nisha AU - Gupta, Jagrati JO - Research Journal of Medical Sciences VL - 18 IS - 10 SP - 599 EP - 603 PY - 2024 DA - 2001/08/19 SN - 1815-9346 DO - makrjms.2024.10.599.603 UR - https://makhillpublications.co/view-article.php?doi=makrjms.2024.10.599.603 KW - Micronized progesterone KW - preterm labor KW - delivery interval KW - gestational age KW - tocolysis AB -

Women with preterm labour that is arrested with tocolytic therapy are at increased risk of recurrent preterm labour. The efficacy of progesterone tocolytic therapy after successful arrest of preterm labour remains controversial Aim of this study to evaluate role of vaginal micronized progesterone in arrested preterm labour. Pregnant women who were arrested with acute tocolysis as evidenced by a 12 hour contraction free period were randomized into study and control groups. The study group received 400 mg of vaginal micronized progesterone daily, while the control group did not receive any drug. The patients were followed up till 37 completed weeks. Maternal and fetal outcomes were compared in both the groups In the present study majority of the women were 21‐25 years age in both the groups, the period of gestation at delivery was significantly (p<0.05) high in progesterone group (37‐40 weeks) as compared to that in control group (34‐36.6 weeks). Lower segment cesarean sections (LSCS) was higher in progesterone group (57.1%) as compared to control group (34.3%). In Recurrence rate of preterm labour was significantly lower (75.7%) in progesterone group as compared to control group (82.8%). Vaginal micronized progesterone as a tocolytic therapy following an episode of arrested pre‐term labor significantly increased the duration to delivery interval., reduces the recurrence of preterm labour and also reduced the rate of Preterm birth.

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