TY  - JOUR
T1  - Characteristics of <I>Serratia Marcescens</I> Strains
AU - Shirshikova, Tatyana V. AU - Nizamutdinova, Elvira Kh. AU - Mardanova, Ayslu M. AU - Sharipova, Margarita R. AU - Bogomolnaya, Lidiya M. 
JO  - Research Journal of Applied Sciences
VL  - 10
IS  - 12
SP  - 911
EP  - 916
PY  - 2015
DA  - 2001/08/19
SN  - 1815-932x
DO  - rjasci.2015.911.916
UR  - https://makhillpublications.co/view-article.php?doi=rjasci.2015.911.916
KW  - Serratia Marcescens
KW  -protease
KW  -nuclease
KW  -antibiotic resistance
KW  -SM6 strain
AB  - One of the most topical issues in the modern world is increase in antibiotic resistance of bacteria. Progressing threat of development of antimicrobial resistance is related to the use of antibiotics for treatment of humans and animals as well as by manufacturing of food products. The annually increasing number of fatal cases is related to the absence of mew antibiotics as well as to great financial costs required for the procedure of implementation thereof in the medical practice. Representatives of Serratia genus are able to cause wide range of infectious diseases. Treatment of such diseases is often hindered because of the multiple antibiotic resistances of bacteria. Within the study we performed identification of phylogenetic affinity of the chromogenic (SM6) and pigment-free (SR41-8000) strains of <I>Serratia Marcescens</I> on the basis of comparison of nucleotide sequences of fragments of the 16S rRNA gene. It was found that the SM6 and SR41-8000 strains are located in different clusters of the phylogenetic tree. Proteolytic and nuclease activity of strains as well as sensitivity to antimicrobial agents of two <I>S. Marcescens</I> strains were compared. Nuclease activity in the cell culture fluid of <I>S. Marcescens</I> SR41-8000 exceeded nuclease activity of the <I>S. Marcescens</I> SM6 strain whereas the extracellular proteolytic activity was higher in the <I>S. Marcescens</I> SM6 strain. The <I>S. Marcescens</I> SM6 strain featured higher resistance to different classes of antibiotics than the <I>S. Marcescens</I> SR41-8000 strain.
ER  -