TY  - JOUR
T1  - Causal Organisms, Pathogenicity, Laboratory Diagnosis and Treatment of Candidiasis
AU - Enan, Gamal AU - EL-Sayed, Talaat I. AU - Atef, Dina AU - Amer, Mahmoud AU - Mahdy, Ahmed 
JO  - Research Journal of Applied Sciences
VL  - 10
IS  - 4
SP  - 115
EP  - 135
PY  - 2015
DA  - 2001/08/19
SN  - 1815-932x
DO  - rjasci.2015.115.135
UR  - https://makhillpublications.co/view-article.php?doi=rjasci.2015.115.135
KW  - Candidiasis
KW  -virulence factors
KW  -diagnosis
KW  -treatment
KW  -natural extract
AB  - A historical overview about candidiasis was provided herein. The main causal pathogens of candidiasis are <I>C. albicans</I>, <I>C. Tropicalis</I>, <I>C. dubliniensis</I>, <I>C. glabrata</I>, <I>C. krusei</I>, <I>C. parapsilosis</I>, <I>C. lusitaniae</I>, <I>C. guilliermonndii</I>, <I>C. kefyr</I>, <I>C. utilis</I>, <I>C. inconspicua</I>, <I>C. rugosa</I> and <I>C. catenulata</I>. There are also few <I>Candida</I> sp., involved in human infection in only immunocompromized patients. The pathogenicity of <I>Candida</I> sp. are due to ability to adhere smooth tissue surfaces, biofilm formation and production of many virulence factors such as hydrolytic enzymes. Candidiasis is diagnosed by microscopic detection, culture media, serology and molecular fingerprints using either DNA or RNA isolated from the causal pathogen. Candidiasis is treated by many synthetic antifungal agents. The antifungal agents in development are discussed in this review study. The recent prospectives about use of natural extracts as an antifungal agents are also discussed.
ER  -