TY  - JOUR
T1  - Histopathological Effects of Silicon Dioxide Nanoparticles on Some Tissues of <i>Labidochromis caeruleus</i> in the Larval Period
AU - Ba&#351;&#305;mo&#287;lu Koca, Y&uuml;cel AU - Cinar, &Uuml;mran 
JO  - Journal of Animal and Veterinary Advances
VL  - 21
IS  - 1
SP  - 1
EP  - 13
PY  - 2022
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2022.1.13
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2022.1.13
KW  - Silicondioxide
KW  -nanoparticle
KW  -Labidochromis caeruleus
KW  -histopathology
KW  -gill
KW  -liver
KW  -eye and brain
AB  - Silicon dioxide is widely used today for
different purposes in engineering, biotechnology,
medicine and in many daily life products. Large-scale
production and use have increased the risk of exposure to
silicon dioxide nanoparticles (SiO<sub>2</sub>NPs). The present
study has focused on the evaluation of this issue by using
a nanoparticle, SiO<sub>2</sub>NP, in an aquatic model organism,
<i>Labidochromis caeruleus</i> larvae. Fish were exposed to
SiO<sub>2</sub>NPs in three different doses and general histological
methods were applied. At the same time,
histopathological changes were categorized by
semiquantitative scoring. Histological sections of gill,
liver, eye and brain tissues were examined under a light
microscope after staining with hematoxylin and eosin.
Distortion of lamellae shapes in gill tissue, rupture and
detachment of primary lamellae, shortening and rupture of
secondary lamellae and separation of epithelium were
observed. Oedema under the capsule in the liver, pycnotic
nucleus in hepatocytes, necrosis in different parts of the
parenchyma and large vacuoles were observed. Thinning
of the corneal layer in the eye tissue, separation of the
lens epithelium and fragmentation of the lens fibres were
noted. In the brain tissue, astrocytes were intensely
observed in the forebrain, medulla oblongata and spinal
cord only in the high dose group. These structural changes
are advanced in gill and liver tissues, moderate in the eye,
and mild in the brain. These findings reveal that even
short-term exposure of fish to SiO<sub>2</sub>NPs may pose a
potential risk.
ER  -