TY  - JOUR
T1  - Effects of Milk Thistle, Artichoke and Olive Extracts in Comparison with Atorvastatin and
Gemfibrozil on Liver Function in Broiler Chicken
AU - Khosravinia, Heshmatollah AU - Tavakolinasab, Fatemeh AU - Masouri, Babak 
JO  - Journal of Animal and Veterinary Advances
VL  - 19
IS  - 2
SP  - 18
EP  - 25
PY  - 2020
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2020.18.25
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2020.18.25
KW  - hepatoprotection
KW  -gemfibrozil
KW  -broiler chicken
KW  -Atorvastatin
KW  -herbal medicine
AB  - Two hundredeighty-eight 10-day old male
Arbor Acres (320±5 g) broiler chicks were used to
compare the responses in liver function to dietary
supplementation of milk thistle (<i>Silybum marianum</i>),
artichoke (<i>Cichorium intybus</i>) and olive (<i>Olea europaea</i>)
extracts with gemfibrozil and atorvastatin, in broiler
chickens fed with a lipogenic diet. Birds raised in the
standard experimental conditions and received a pelleted
grower diet (control) supplemented with milk thistle
(250 mg kg<sup>&#150;1</sup>), artichoke (200 mg kg<sup>&#150;1</sup>), olive (150 mg
kg<sup>&#150;1</sup>) extracts, atorvastatin (20 mg kg<sup>&#150;1</sup>) and gemfibrozil
(1800 mg kg<sup>&#150;1</sup>) up to day 42 of age. Liver weight and
liver fat parentage were 1.62 and 6.04%, respectively, in
the birds fed with the un-supplemented basal diet (control)
and modified by +0.21 and -2.13, +0.11 and -1.21, +0.14
and -1.40, -0.07 and -2.36, +0.07 and -0.38% in the birds
received milk thistle, artichoke, olive extracts, gemfibrozil
and atorvastatin, respectively. The milk thistle-added diet
elicited significant reduction in serum activity of
Aspartate amino transferase and Alanine aminotransferase
at day 35 of age. Dietary olive extract at 150 mg kg<sup>&#150;1</sup>
reduced liver fat at day 35 of age compared with those
grown on the basal diet (p&lt;0.05). Plasma triglycerides
level was lower (p&lt;0.05) in the birds fed with diets
enriched with artichoke (34.86 mg dL<sup>&#150;1</sup>) and olive extract
(40.63 mg dL<sup>&#150;1</sup>) compared with those fed with the
supplemented control diet at day 35 of age. It was
concluded that milk thistle exerted greater promising
hepatoprotective effects compared with other remedies.
Gemfibrozil exhibited a greater hepatoprotective and
blood lipid lowering effect than atorvastatin.
ER  -