TY  - JOUR
T1  - Nephroprotective Effects of Cinnamon and/or Parsley Oils against
Gentamicin-Induced Nephrotoxicity in Rats
AU - Aboubakr, Mohamed AU - Abugomaa, Amira AU - Elbadawy, Mohamed AU - Elkomy, Ashraf AU - Medhat, Yara 
JO  - Journal of Animal and Veterinary Advances
VL  - 18
IS  - 7
SP  - 201
EP  - 207
PY  - 2019
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2019.201.207
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2019.201.207
KW  - nephrotoxicity
KW  -rats
KW  -oxidative stress
KW  -gentamicin
KW  -Cinnamon
KW  -parsley
AB  - In the present study, the nephroprotective potentials of cinnamon and/or parsley oils was assessed
on gentamicin (GM)-induced nephrotoxicity in rats. About 49 male rats were assigned randomly into 7 equal
groups (7 rats each). Group 1-3: were orally administered normal saline, cinnamon oil (400 mg kg<sup>&#150;1</sup> b.wt.) and
parsley oil (200 mg kg<sup>&#150;1</sup> b.wt.), respectively, once daily for 30 consecutive days. Group 4: rats in this group
were intraperitoneally injected with GM (100 mg kg<sup>&#150;1</sup> b.wt.) in the last 10 days (20-30<sup>th</sup> day) of the experiment.
Group 5: rats in this group were given cinnamon and GM while rats in group 6 were administered parsley and
GM. Group 7: rats in this group were administered cinnamon and parsley plus GM. At the end of the
experiment, rats were sacrificed, serum samples and kidney specimens were collected for biochemical and
oxidative status evaluation. Rats administered GM alone showed significant increases in serum concentrations
of creatinine, urea and glucose while renal tissue levels of superoxide dismutase, catalase and glutathione
reductase were significantly declined. Additionally, the malondialdehyde level was significantly elevated in
kidney tissues. Also, GM administration caused renal histopathological alterations. The altered levels of various
parameters provoked by GM toxicity were restored towards normal levels by cinnamon and/or parsley oils
administration. These results suggested the nephroprotective potentials of cinnamon and/or parsley oils in rats,
probably triggered by their antioxidant phytoconstituents.
ER  -