TY  - JOUR
T1  - Evaluation of the Effect of STZ-Induced Diabetes on Oocyte Morphology and
Subsequent Embryo Development in Superovulated Mice
AU - Budak, Ozcan AU - Yalcinkaya, Ender AU - Caliskan, Eray AU - Alyuruk, Begum AU - Ceylan, Sureyya 
JO  - Journal of Animal and Veterinary Advances
VL  - 14
IS  - 11
SP  - 345
EP  - 350
PY  - 2015
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2015.345.350
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2015.345.350
KW  - Streptozotocin
KW  -type 1 diabetes
KW  -superovulation
KW  -mice
KW  -Turkey
AB  - Type 1 diabetes was shown to affect oocyte quality and subsequent embryo development. In this
study, we aimed to evaluate the effect of diabetes on oocyte quality based on morphological criteria and
subsequent embryo development in a mouse model. Female CD 1 mice were used as the experimental animals
for superovulation and male mice were used as the source of spermatozoa for IVF. Significant differences were
observed in the morphological criteria such as perivitelline space, zona pellucida and polar bodies between both
groups (p<0.05). Following superovulation and IVF, embryo quality and blastocyst development rate were
compared between groups and it was observed that embryo quality and blastocyst development rate were
superior in control group compared to diabetic one (p<0.05). These results suggest that even
chemically-induced diabetes may show adverse effects on female reproductive cells and subsequent embryo
development.
ER  -