TY  - JOUR
T1  - Effect of Alanine Supplementation on Vaccine Immunized Mice
AU - Zhang, Pan AU - Wang, Jianlong 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 15
SP  - 1266
EP  - 1270
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.1266.1270
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.1266.1270
KW  - Alanine
KW  -isonitrogenous control
KW  -vaccine
KW  -GSH-PX
KW  -mice
AB  - This study was conducted to test the immunostimulatory effect 
  of graded dose of alanine supplementation on inactivated vaccine immunized mice. 
  Animals were randomly divided into five groups: mice were immunized with inactivated 
  vaccines, mice were treated with dietary 0.5% alanine supplementation and immunized 
  with inactivated vaccines, mice were treated with dietary 1.0% alanine supplementation 
  and immunized with inactivated vaccines, mice were treated with dietary 2.0% 
  alanine supplementation and immunized with inactivated vaccines and all the 
  mice immunized with PBS. Results found that alanine supplementation has little 
  significant effect on serum antibody production, serum interleukin-1 beta and 
  8 levels and survival rate of mice after challenge. However, higher dose of 
  alanine supplementation increased serum GSH-PX activity compared to the lower 
  dose of alanine supplementation. Collectively, dietary alanine supplementation 
  has little effect on the immune parameters in vaccine immunized mice indicating 
  alanine can be used as isonitrogenous control to study the immune regulatory 
  function of other amino acids.
ER  -